Acceptability of oral typhoid vaccine in Thai children.

Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.

Humoral Immunity in Two Groups of Children Induced by Two Supplemental Doses of Oral Polio Vaccine, and in the Umbilical Cord Blood

Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan.

BACKGROUND Typhoid fever is endemic in Karachi, with an incidence among children ranging from 170 to 450 per 100,000 child-years. Vaccination strategies are important for prevention, and the Vi capsular polysaccharide (ViCPS) vaccine has been shown to be effective in reducing the burden of typhoid fever. METHODS A cluster randomized trial was conducted in three low socioeconomic urban squatte...

A Randomised Trial Evaluating the Safety and Immunogenicity of the Novel Single Oral Dose Typhoid Vaccine M01ZH09 in Healthy Vietnamese Children

BACKGROUND The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages. M01ZH09 is a live oral single dose candidate typhoid vaccine containing Salmonella enterica serovar Typhi (Ty2 aroC(-)ssaV(-)) ZH9 with two independently attenuating deletions. Studies in healthy adults demonstrated immun...

Safety and Immunogenicity of Salmonella Typhi Vi conjugate vaccine (Peda TyphTM) in children upto five years

Background: Conjugate typhoid vaccine can prevent increasing cases of typhoid in younger children. Commercially available conjugate vaccine has limited studies to support its use. Aims: To study the safety and immunogenicity of Vi conjugate typhoid vaccine (PedaTyph TM ). Materials and Methods: Four hundred children with age <5 years were randomised to receive either one dose (Group A) or two d...